Diagnostic Assays for Identification of Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer

In series dominated by adenocarcinoma histology, approximately 5% of non–small cell lung cancers (NSCLCs) harbor an anaplastic lymphoma kinase (ALK) gene rearrangement. Crizotinib, a tyrosine kinase inhibitor with significant activity against ALK, has demonstrated high response rates and prolonged p...

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Autori principali: Weickhardt, Andrew J., Aisner, Dara L., Franklin, Wilbur A., Varella-Garcia, Marileila, Doebele, Robert C., Camidge, D. Ross
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935240/
https://ncbi.nlm.nih.gov/pubmed/23280244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27913
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