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The Role of Bile Salt Export Pump Gene Repression in Drug-Induced Cholestatic Liver Toxicity

The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury. Accumulating evidence suggests that many drugs can cause cholestasis th...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Garzel, Brandy, Yang, Hui, Zhang, Lei, Huang, Shiew-Mei, Polli, James E., Wang, Hongbing
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935137/
https://ncbi.nlm.nih.gov/pubmed/24335466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054189
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