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Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest, Axon Wrapping, and Myelin Gene Expression

Myelin membrane, which ensheaths axons, has an unusually high amount of cholesterol. Cholesterol influences membrane fluidity and assembles lipid-rich microdomains within membranes, and some studies have shown that cholesterol is important for myelination. How cholesterol influences the development...

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Detalhes bibliográficos
Main Authors: Mathews, Emily S., Mawdsley, David J., Walker, Macie, Hines, Jacob H., Pozzoli, Marina, Appel, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935092/
https://ncbi.nlm.nih.gov/pubmed/24573296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4587-13.2014
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