Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells

O(6)-methylguanine DNA methyltransferase (MGMT) can remove DNA alkylation adducts, thereby repairing damaged DNA and contributing to the drug resistance of gliomas to alkylating agents. In addition, glioma stem-like cells (GSCs) have been demonstrated to be involved in the recurrence and treatment r...

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Detalhes bibliográficos
Main Authors: Qiu, Zhi-Kun, Shen, Dong, Chen, Yin-Sheng, Yang, Qun-Ying, Guo, Cheng-Cheng, Feng, Bing-Hong, Chen, Zhong-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Sun Yat-sen University Cancer Center 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935013/
https://ncbi.nlm.nih.gov/pubmed/23958055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5732/cjc.012.10236
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