The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles

Microtubule-associated protein 2 (MAP2) and Tau are abundant neuronal microtubule-associated proteins. Both proteins have highly homologous carboxyl-terminal sequences that function as microtubule-binding domains. Whereas Tau is widely accepted as a pathoetiological factor in human tauopathies, incl...

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Main Authors: Xie, Ce, Miyasaka, Tomohiro, Yoshimura, Satomi, Hatsuta, Hiroyuki, Yoshina, Sawako, Kage-Nakadai, Eriko, Mitani, Shohei, Murayama, Shigeo, Ihara, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934940/
https://ncbi.nlm.nih.gov/pubmed/24587039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089796
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