Nuclear Interaction between ADR-Induced p65 and p53 Mediates Cardiac Injury in iNOS (−/−) Mice

Adriamycin (ADR) treatment causes an imbalance in the levels of nitric oxide ((•)NO) and superoxide (O(2) (•−)) production leading to cardiac injury. Previously we demonstrated that mice lacking inducible nitric oxide synthase (iNOS) have increased oxidative stress and mitochondrial injury. The mole...

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Main Authors: Cole, Marsha P., Tangpong, Jitbanjong, Oberley, Terry D., Chaiswing, Luksana, Kiningham, Kinsley K., St. Clair, Daret K.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934890/
https://ncbi.nlm.nih.gov/pubmed/24586632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089251
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