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siRNA-Mediated Down-regulation of Ceramide Synthase 1 Leads to Apoptotic Resistance in Human Head and Neck Squamous Carcinoma Cells After Photodynamic Therapy

BACKGROUND: The effectiveness of photodynamic therapy (PDT) for cancer treatment correlates with apoptosis. We previously observed that the knockdown of ceramide synthase 6, an enzyme from the de novo sphingolipid biosynthesis pathway, is associated with marked reduction in C18-dihydroceramide and m...

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Detalhes bibliográficos
Main Authors: SEPAROVIC, DUSKA, BREEN, PAUL, JOSEPH, NICHOLAS, BIELAWSKI, JACEK, PIERCE, JASON S., VAN BUREN, ERIC, GUDZ, TATYANA I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934872/
https://ncbi.nlm.nih.gov/pubmed/22753704
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