Therapeutic modulation of eIF2α-phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset neurodegenerative disease primarily impacting motor neurons. A unifying feature of many proteins associated with ALS, including TDP-43 and Ataxin-2, is that they localize to stress granules. Unexpectedly, we found that genes that modulate st...

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Main Authors: Kim, Hyung-Jun, Raphael, Alya R., LaDow, Eva S., McGurk, Leeanne, Weber, Ross, Trojanowski, John Q., Lee, Virginia M.-Y., Finkbeiner, Steven, Gitler, Aaron D., Bonini, Nancy M.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934366/
https://ncbi.nlm.nih.gov/pubmed/24336168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2853
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