CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis

Successful host defense against numerous pulmonary infections depends on bacterial clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN accumulation can result in life-threatening lung injury. Local expression of CXC chemokines is critical for PMN recruitment. The impact of chemo...

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Detalhes bibliográficos
Main Authors: Nouailles, Geraldine, Dorhoi, Anca, Koch, Markus, Zerrahn, Jens, Weiner, January, Faé, Kellen C., Arrey, Frida, Kuhlmann, Stefanie, Bandermann, Silke, Loewe, Delia, Mollenkopf, Hans-Joachim, Vogelzang, Alexis, Meyer-Schwesinger, Catherine, Mittrücker, Hans-Willi, McEwen, Gayle, Kaufmann, Stefan H.E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934185/
https://ncbi.nlm.nih.gov/pubmed/24509076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72030
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