MBNL proteins repress embryonic stem cell-specific alternative splicing and reprogramming

Previous investigations of the core gene regulatory circuitry that controls embryonic stem cell (ESC) pluripotency have largely focused on the roles of transcription, chromatin and non-coding RNA regulators(1–3). Alternative splicing (AS) represents a widely acting mode of gene regulation(4–8), yet...

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Main Authors: Han, Hong, Irimia, Manuel, Ross, P. Joel, Sung, Hoon-Ki, Alipanahi, Babak, David, Laurent, Golipour, Azadeh, Gabut, Mathieu, Michael, Iacovos P., Nachman, Emil N., Wang, Eric, Trcka, Dan, Thompson, Tadeo, O’Hanlon, Dave, Slobodeniuc, Valentina, Barbosa-Morais, Nuno L., Burge, Christopher B., Moffat, Jason, Frey, Brendan J., Nagy, Andras, Ellis, James, Wrana, Jeffrey L., Blencowe, Benjamin J.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933998/
https://ncbi.nlm.nih.gov/pubmed/23739326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12270
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