Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in vivo significance of this regulation. We stud...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Solana, Jordi, Irimia, Manuel, Ayoub, Salah, Orejuela, Marta Rodriguez, Zywitza, Vera, Jens, Marvin, Tapial, Javier, Ray, Debashish, Morris, Quaid, Hughes, Timothy R, Blencowe, Benjamin J, Rajewsky, Nikolaus
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Developmental Biology and Stem Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978528/
https://ncbi.nlm.nih.gov/pubmed/27502555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16797
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