Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in vivo significance of this regulation. We stud...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Solana, Jordi, Irimia, Manuel, Ayoub, Salah, Orejuela, Marta Rodriguez, Zywitza, Vera, Jens, Marvin, Tapial, Javier, Ray, Debashish, Morris, Quaid, Hughes, Timothy R, Blencowe, Benjamin J, Rajewsky, Nikolaus
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2016
Aiheet:
Developmental Biology and Stem Cells
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978528/
https://ncbi.nlm.nih.gov/pubmed/27502555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16797
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia