טוען...
Two surfaces of cytochrome b(5) with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries
Conserved human cytochrome b(5) (b(5)) residues D58 and D65 are critical for interactions with CYP2E1 and CYP2C19, whereas E48 and E49 are essential for stimulating the 17,20-lyase activity of CYP17A1. Here, we show that b(5) mutations E48G, E49G, D58G, and D65G have reduced capacity to stimulate CY...
שמור ב:
| Main Authors: | , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2013
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3933929/ https://ncbi.nlm.nih.gov/pubmed/24256945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2013.11.001 |
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