A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma

The chromatin modifier EZH2 is overexpressed and associated with inferior outcome in mantle cell lymphoma (MCL). Recently, we demonstrated preferential DNA methylation of HOX genes in MCL compared with chronic lymphocytic leukemia (CLL), despite these genes not being expressed in either entity. Sinc...

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Detalhes bibliográficos
Main Authors: Kanduri, Meena, Sander, Birgitta, Ntoufa, Stavroula, Papakonstantinou, Nikos, Sutton, Lesley-Ann, Stamatopoulos, Kostas, Kanduri, Chandrasekhar, Rosenquist, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933489/
https://ncbi.nlm.nih.gov/pubmed/24107828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.26546
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