Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia

Microenvironmental stimuli affect EZH2 expression and function in CLL. Combined B-cell signaling and EZH2 inhibition showed synergistic effects on primary CLL cells.

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Chartomatsidou, Elisavet, Ntoufa, Stavroula, Kotta, Konstantia, Rovida, Alessandra, Akritidou, Maria Anna, Belloni, Daniela, Ferrero, Elisabetta, Trangas, Theoni, Stavroyianni, Niki, Anagnostopoulos, Achilles, Rosenquist, Richard, Ghia, Paolo, Papakonstantinou, Nikos, Stamatopoulos, Kostas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Stimulus Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595263/
https://ncbi.nlm.nih.gov/pubmed/31227476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018030262
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