Structural basis for nuclear import of splicing factors by human Transportin 3

Transportin 3 (Tnpo3, Transportin-SR2) is implicated in nuclear import of splicing factors and HIV-1 replication. Herein, we show that the majority of cellular Tnpo3 binding partners contain arginine-serine (RS) repeat domains and present crystal structures of human Tnpo3 in its free as well as GTPa...

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Autores principales: Maertens, Goedele N., Cook, Nicola J., Wang, Weifeng, Hare, Stephen, Gupta, Saumya Shree, Öztop, Ilker, Lee, KyeongEun, Pye, Valerie E., Cosnefroy, Ophélie, Snijders, Ambrosius P., KewalRamani, Vineet N., Fassati, Ariberto, Engelman, Alan, Cherepanov, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932936/
https://ncbi.nlm.nih.gov/pubmed/24449914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320755111
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