Structural basis for nuclear import of splicing factors by human Transportin 3

Transportin 3 (Tnpo3, Transportin-SR2) is implicated in nuclear import of splicing factors and HIV-1 replication. Herein, we show that the majority of cellular Tnpo3 binding partners contain arginine-serine (RS) repeat domains and present crystal structures of human Tnpo3 in its free as well as GTPa...

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Bibliografiske detaljer
Main Authors: Maertens, Goedele N., Cook, Nicola J., Wang, Weifeng, Hare, Stephen, Gupta, Saumya Shree, Öztop, Ilker, Lee, KyeongEun, Pye, Valerie E., Cosnefroy, Ophélie, Snijders, Ambrosius P., KewalRamani, Vineet N., Fassati, Ariberto, Engelman, Alan, Cherepanov, Peter
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932936/
https://ncbi.nlm.nih.gov/pubmed/24449914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320755111
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