Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation

Platelet-derived growth factors (PDGFs) are critical for development; their over-expression is associated with fibrogenesis. Full-length PDGF-C is secreted as an inactive dimer, requiring cleavage to allow receptor binding. Previous studies indicate that tissue-type plasminogen activator (tPA) is th...

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Detalhes bibliográficos
Main Authors: Riehle, Kimberly J., Johnson, Melissa M., Johansson, Fredrik, Bauer, Renay L., Hayes, Brian J., Gilbertson, Debra G., Haran, Aaron C., Fausto, Nelson, Campbell, Jean S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932705/
https://ncbi.nlm.nih.gov/pubmed/24269585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.11.013
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