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Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neurons
The neurotransmitter dopamine (DA) is important for numerous biological functions, including control of movement. Oxidation of DA to highly toxic and reactive species has been hypothesized to contribute to the selective neurodegeneration observed in Parkinson's disease (PD). DA catabolism is in...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932615/ https://ncbi.nlm.nih.gov/pubmed/24262193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1353-8020(13)70019-1 |
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