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The Marine Cyanobacterial Metabolite Gallinamide A is a Potent and Selective Inhibitor of Human Cathepsin L

A number of marine natural products are potent inhibitors of proteases, an important drug target class in human diseases. Hence, marine cyanobacterial extracts were assessed for inhibitory activity to human cathepsin L. Herein, we have shown that gallinamide A potently and selectively inhibits the h...

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Detalhes bibliográficos
Main Authors: Miller, Bailey, Friedman, Aaron J, Choi, Hyukjae, Hogan, James, McCammon, J. Andrew, Hook, Vivian, Gerwick, William H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932306/
https://ncbi.nlm.nih.gov/pubmed/24364476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np400727r
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