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The Marine Cyanobacterial Metabolite Gallinamide A is a Potent and Selective Inhibitor of Human Cathepsin L

A number of marine natural products are potent inhibitors of proteases, an important drug target class in human diseases. Hence, marine cyanobacterial extracts were assessed for inhibitory activity to human cathepsin L. Herein, we have shown that gallinamide A potently and selectively inhibits the h...

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Main Authors: Miller, Bailey, Friedman, Aaron J, Choi, Hyukjae, Hogan, James, McCammon, J. Andrew, Hook, Vivian, Gerwick, William H.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932306/
https://ncbi.nlm.nih.gov/pubmed/24364476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np400727r
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