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The Marine Cyanobacterial Metabolite Gallinamide A is a Potent and Selective Inhibitor of Human Cathepsin L

A number of marine natural products are potent inhibitors of proteases, an important drug target class in human diseases. Hence, marine cyanobacterial extracts were assessed for inhibitory activity to human cathepsin L. Herein, we have shown that gallinamide A potently and selectively inhibits the h...

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Autori principali: Miller, Bailey, Friedman, Aaron J, Choi, Hyukjae, Hogan, James, McCammon, J. Andrew, Hook, Vivian, Gerwick, William H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932306/
https://ncbi.nlm.nih.gov/pubmed/24364476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np400727r
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