Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model

Two characteristic features of malignant gliomas (MG) are the presence of hypoxia and accumulation of regulatory T cells (Treg). Heme-oxygenase-1 (HO1) is a cytoprotective enzyme expressed in high level by Tregs in glioma. In this study, we show that higher HO1 expression in Treg is associated with...

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Bibliographic Details
Main Authors: Dey, Mahua, Chang, Alan L., Wainwright, Derek A., Ahmed, Atique U., Han, Yu, Balyasnikova, Irina V., Lesniak, Maciej S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932190/
https://ncbi.nlm.nih.gov/pubmed/24268287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2013.10.012
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