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Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

3-Deazaadenosine (deazaAdo) inhibits lymphocyte-mediated cytolysis in vitro at micromolar concentrations and is potentiated markedly in this activity by L-homocysteine thiolactone. DeazaAdo alone causes a rapid, dose-dependent buildup of S-[(3)H]adenosylhomocysteine (AdoHcy) and S-[(3)H]adenosylmeth...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Zimmerman, Thomas P., Wolberg, Gerald, Duncan, Gail S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1978
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393151/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/216017/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.12.6220
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