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Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

3-Deazaadenosine (deazaAdo) inhibits lymphocyte-mediated cytolysis in vitro at micromolar concentrations and is potentiated markedly in this activity by L-homocysteine thiolactone. DeazaAdo alone causes a rapid, dose-dependent buildup of S-[(3)H]adenosylhomocysteine (AdoHcy) and S-[(3)H]adenosylmeth...

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Detalhes bibliográficos
Main Authors: Zimmerman, Thomas P., Wolberg, Gerald, Duncan, Gail S.
Formato: Artigo
Idioma:Inglês
Publicado em: 1978
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC393151/
https://ncbi.nlm.nih.gov/pubmed/216017
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