Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality

BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific Cdk5 conditional knockout (cKO) mice displayed an early lethality associat...

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Autori principali: Utreras, Elias, Hamada, Ryusuke, Prochazkova, Michaela, Terse, Anita, Takahashi, Satoru, Ohshima, Toshio, Kulkarni, Ashok B
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931315/
https://ncbi.nlm.nih.gov/pubmed/24495352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-28
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