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Actinomycin D inhibits initiation of DNA replication in mammalian cells.

Mammalian (Chinese hamster ovary) cells were synchronized in the division cycle and blocked at the beginning of S phase with fluorodeoxyuridine. Traces of thymidine in the medium allowed cells to enter S phase and initiate DNA replication at some origins. For many hours after the traces of thymidine...

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Bibliografiske detaljer
Main Authors: Guy, A L, Taylor, J H
Format: Artigo
Sprog:Inglês
Udgivet: 1978
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC393123/
https://ncbi.nlm.nih.gov/pubmed/282626
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