Spermine Attenuates the Action of the DNA Intercalator, Actinomycin D, on DNA Binding and the Inhibition of Transcription and DNA Replication

The anticancer activity of DNA intercalators is related to their ability to intercalate into the DNA duplex with high affinity, thereby interfering with DNA replication and transcription. Polyamines (spermine in particular) are almost exclusively bound to nucleic acids and are involved in many cellu...

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Detalhes bibliográficos
Main Authors: Wang, Sheng-Yu, Lee, Yueh-Luen, Lai, Yi-Hua, Chen, Jeremy J. W., Wu, Wen-Lin, Yuann, Jeu-Ming P., Su, Wang-Lin, Chuang, Show-Mei, Hou, Ming-Hon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493566/
https://ncbi.nlm.nih.gov/pubmed/23144800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047101
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