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Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression

The mammalian circadian clock is a molecular oscillator composed of a feedback loop that involves transcriptional activators CLOCK and BMAL1, and repressors Cryptochrome (CRY) and Period (PER). Here we show that a direct CLOCK·BMAL1 target gene, Gm129, is a novel regulator of the feedback loop. ChIP...

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Detalhes bibliográficos
Main Authors: Annayev, Yunus, Adar, Sheera, Chiou, Yi-Ying, Lieb, Jason D., Sancar, Aziz, Ye, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931061/
https://ncbi.nlm.nih.gov/pubmed/24385426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534651
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