Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction

Tissue transglutaminase (TG2) mediates protein crosslinking through generation of ε−(γ-glutamyl) lysine isopeptide bonds and promotes cell adhesion through interaction with fibronectin (FN) and integrins. Cell adhesion to the peritoneal matrix regulated by TG2 facilitates ovarian cancer disseminatio...

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Detalhes bibliográficos
Main Authors: Yakubov, Bakhtiyor, Chen, Lan, Belkin, Alexey M., Zhang, Sheng, Chelladurai, Bhadrani, Zhang, Zhong-Yin, Matei, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930694/
https://ncbi.nlm.nih.gov/pubmed/24586660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089285
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