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Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction
Tissue transglutaminase (TG2) mediates protein crosslinking through generation of ε−(γ-glutamyl) lysine isopeptide bonds and promotes cell adhesion through interaction with fibronectin (FN) and integrins. Cell adhesion to the peritoneal matrix regulated by TG2 facilitates ovarian cancer disseminatio...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930694/ https://ncbi.nlm.nih.gov/pubmed/24586660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089285 |
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