Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism

Metformin inhibits cancer cell proliferation and epidemiology studies suggest an association with increased survival in cancer patients taking metformin, however, the mechanism by which metformin improves cancer outcomes remains controversial. To explore how metformin might directly affect cancer ce...

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Main Authors: Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Davidson, Shawn M., Wirth, Gregory J., Fiske, Brian, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfredo, Patnaik, Akash, Jose Blouin, Marie, Cantley, Lewis C., Guarente, Leonard, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930683/
https://ncbi.nlm.nih.gov/pubmed/23687346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0080
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