Zonisamide Attenuates α-Synuclein Neurotoxicity by an Aggregation-Independent Mechanism in a Rat Model of Familial Parkinson’s Disease

The anti-epileptic agent zonisamide (ZNS) has been shown to exert protective effects in neurotoxin-based mouse models of Parkinson disease. However, it is unknown whether ZNS can attenuate toxicity of familial Parkinson’s disease-causing gene products. In this study, we investigated the effects of Z...

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Autori principali: Arawaka, Shigeki, Fukushima, Shingo, Sato, Hiroyasu, Sasaki, Asuka, Koga, Kaori, Koyama, Shingo, Kato, Takeo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930669/
https://ncbi.nlm.nih.gov/pubmed/24586512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089076
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