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Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest derived cell line
Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF) is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930615/ https://ncbi.nlm.nih.gov/pubmed/23455321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.39 |
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