Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection

Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M. tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome, whose pH is slightly acidic, and where access to nutrients is limited. Understanding how the bacillus extracts and incorporates nutrients from...

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Main Authors: Gouzy, Alexandre, Larrouy-Maumus, Gérald, Bottai, Daria, Levillain, Florence, Dumas, Alexia, Wallach, Joshua B., Caire-Brandli, Irène, de Chastellier, Chantal, Wu, Ting-Di, Poincloux, Renaud, Brosch, Roland, Guerquin-Kern, Jean-Luc, Schnappinger, Dirk, Sório de Carvalho, Luiz Pedro, Poquet, Yannick, Neyrolles, Olivier
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930563/
https://ncbi.nlm.nih.gov/pubmed/24586151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003928
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