Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant inactivated in AnsP1 revealed the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gouzy, Alexandre, Larrouy-Maumus, Gérald, Wu, Ting-Di, Peixoto, Antonio, Levillain, Florence, Lugo-Villarino, Geanncarlo, Gerquin-Kern, Jean-Luc, de Carvalho, Luiz Pedro Sório, Poquet, Yannick, Neyrolles, Olivier
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856356/
https://ncbi.nlm.nih.gov/pubmed/24077180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1355
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