Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant inactivated in AnsP1 revealed the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the...

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Bibliographic Details
Main Authors: Gouzy, Alexandre, Larrouy-Maumus, Gérald, Wu, Ting-Di, Peixoto, Antonio, Levillain, Florence, Lugo-Villarino, Geanncarlo, Gerquin-Kern, Jean-Luc, de Carvalho, Luiz Pedro Sório, Poquet, Yannick, Neyrolles, Olivier
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856356/
https://ncbi.nlm.nih.gov/pubmed/24077180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1355
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