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Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism
The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP ortholog) play a key role in DNA damage checkpoint responses in budding yeast. Previous studies have established the model in which Ddc1, a subunit of the checkpoint clamp, and Dpb11, related to TopBP1, activate Mec1 directly and con...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930518/ https://ncbi.nlm.nih.gov/pubmed/24586187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004136 |
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