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Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

BACKGROUND: Metformin is an approved drug prescribed for diabetes. Its role as an anti-cancer agent has drawn significant attention because of its minimal side effects and low cost. However, its mechanism of anti-tumour action has not yet been fully clarified. METHODS: The effect on cell growth was...

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Main Authors: Demir, Ummuhan, Koehler, Andrea, Schneider, Rainer, Schweiger, Susann, Klocker, Helmut
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929757/
https://ncbi.nlm.nih.gov/pubmed/24484909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-52
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