Cystic Fibrosis Bronchial Epithelial Cells Are Lipointoxicated by Membrane Palmitate Accumulation

The F508del-CFTR mutation, responsible for Cystic Fibrosis (CF), leads to the retention of the protein in the endoplasmic reticulum (ER). The mistrafficking of this mutant form can be corrected by pharmacological chaperones, but these molecules showed limitations in clinical trials. We therefore hyp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Payet, Laurie-Anne, Kadri, Linette, Giraud, Sébastien, Norez, Caroline, Berjeaud, Jean Marc, Jayle, Christophe, Mirval, Sandra, Becq, Frédéric, Vandebrouck, Clarisse, Ferreira, Thierry
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929646/
https://ncbi.nlm.nih.gov/pubmed/24586495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089044
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak