Cystic Fibrosis Bronchial Epithelial Cells Are Lipointoxicated by Membrane Palmitate Accumulation

The F508del-CFTR mutation, responsible for Cystic Fibrosis (CF), leads to the retention of the protein in the endoplasmic reticulum (ER). The mistrafficking of this mutant form can be corrected by pharmacological chaperones, but these molecules showed limitations in clinical trials. We therefore hyp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Payet, Laurie-Anne, Kadri, Linette, Giraud, Sébastien, Norez, Caroline, Berjeaud, Jean Marc, Jayle, Christophe, Mirval, Sandra, Becq, Frédéric, Vandebrouck, Clarisse, Ferreira, Thierry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929646/
https://ncbi.nlm.nih.gov/pubmed/24586495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089044
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge