Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin

A disulfide-linked conjugate of concanavalin A (Con A) and fragment A from diphtheria toxin has been synthesized and shown to be toxic for HeLa (human), Chinese hamster ovary (CHO), and SV3T3 (murine) cells. The conjugate was constructed by first coupling cystamine to Con A with a carbodiimide reage...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gilliland, D. Gray, Collier, R. John, Moehring, Joan M., Moehring, Thomas J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1978
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392954/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/281682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.11.5319
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