Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin

A disulfide-linked conjugate of concanavalin A (Con A) and fragment A from diphtheria toxin has been synthesized and shown to be toxic for HeLa (human), Chinese hamster ovary (CHO), and SV3T3 (murine) cells. The conjugate was constructed by first coupling cystamine to Con A with a carbodiimide reage...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gilliland, D. Gray, Collier, R. John, Moehring, Joan M., Moehring, Thomas J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1978
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392954/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/281682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.11.5319
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