Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: A potential new approach for the treatment of hyperinsulinemic hypoglycemia

Novel therapies are needed for the treatment of hypoglycemia resulting from both endogenous and exogenous hyperinsulinema. To provide a potential new treatment option, we identified XMetD, an allosteric monoclonal antibody to the insulin receptor (INSR) that was isolated from a human antibody phage...

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Auteurs principaux: Corbin, John A, Bhaskar, Vinay, Goldfine, Ira D, Issafras, Hassan, Bedinger, Daniel H, Lau, Angela, Michelson, Kristen, Gross, Lisa M, Maddux, Betty A, Kuan, Hua F, Tran, Catarina, Lao, Llewelyn, Handa, Masahisa, Watson, Susan R, Narasimha, Ajay J, Zhu, Shirley, Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D, Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Lee, Steve R, Wong, Steve, Wilcock, Diane, Rubin, Paul, White, Mark L
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929448/
https://ncbi.nlm.nih.gov/pubmed/24423625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26871
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