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Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
Here we report the design and production of an antibody-fluorophore conjugate (AFC) as a non-toxic model of an antibody-drug conjugate (ADC). This AFC is based on the conjugation of dansyl sulfonamide ethyl amine (DSEA)-linker maleimide on interchain cysteines of trastuzumab used as a reference anti...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Landes Bioscience
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929440/ https://ncbi.nlm.nih.gov/pubmed/24135617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26773 |
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