Loading...
Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
Here we report the design and production of an antibody-fluorophore conjugate (AFC) as a non-toxic model of an antibody-drug conjugate (ADC). This AFC is based on the conjugation of dansyl sulfonamide ethyl amine (DSEA)-linker maleimide on interchain cysteines of trastuzumab used as a reference anti...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2014
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929440/ https://ncbi.nlm.nih.gov/pubmed/24135617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26773 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|