Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the ectopic differentiation of early embryos into trophoblast. Here, we further explore the role of Oct4 in blastocys...

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Autors principals: Le Bin, Gloryn Chia, Muñoz-Descalzo, Silvia, Kurowski, Agata, Leitch, Harry, Lou, Xinghua, Mansfield, William, Etienne-Dumeau, Charles, Grabole, Nils, Mulas, Carla, Niwa, Hitoshi, Hadjantonakis, Anna-Katerina, Nichols, Jennifer
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2014
Matèries:
Stem Cells and Regeneration
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929414/
https://ncbi.nlm.nih.gov/pubmed/24504341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.096875
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