Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the ectopic differentiation of early embryos into trophoblast. Here, we further explore the role of Oct4 in blastocys...

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Hlavní autoři: Le Bin, Gloryn Chia, Muñoz-Descalzo, Silvia, Kurowski, Agata, Leitch, Harry, Lou, Xinghua, Mansfield, William, Etienne-Dumeau, Charles, Grabole, Nils, Mulas, Carla, Niwa, Hitoshi, Hadjantonakis, Anna-Katerina, Nichols, Jennifer
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2014
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929414/
https://ncbi.nlm.nih.gov/pubmed/24504341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.096875
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