Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing

Trithorax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins, stimulates enhancer-dependent transcription, and establishes a ‘cellular memory’ of active transcription of PcG-regulated genes. The mechanisms underlying these TRX functions remain largely unknown, but are presumed t...

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Detalhes bibliográficos
Main Authors: Tie, Feng, Banerjee, Rakhee, Saiakhova, Alina R., Howard, Benny, Monteith, Kelsey E., Scacheri, Peter C., Cosgrove, Michael S., Harte, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929413/
https://ncbi.nlm.nih.gov/pubmed/24550119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.102392
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