Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To...

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Hauptverfasser: Lange, Leslie A., Hu, Youna, Zhang, He, Xue, Chenyi, Schmidt, Ellen M., Tang, Zheng-Zheng, Bizon, Chris, Lange, Ethan M., Smith, Joshua D., Turner, Emily H., Jun, Goo, Kang, Hyun Min, Peloso, Gina, Auer, Paul, Li, Kuo-ping, Flannick, Jason, Zhang, Ji, Fuchsberger, Christian, Gaulton, Kyle, Lindgren, Cecilia, Locke, Adam, Manning, Alisa, Sim, Xueling, Rivas, Manuel A., Holmen, Oddgeir L., Gottesman, Omri, Lu, Yingchang, Ruderfer, Douglas, Stahl, Eli A., Duan, Qing, Li, Yun, Durda, Peter, Jiao, Shuo, Isaacs, Aaron, Hofman, Albert, Bis, Joshua C., Correa, Adolfo, Griswold, Michael E., Jakobsdottir, Johanna, Smith, Albert V., Schreiner, Pamela J., Feitosa, Mary F., Zhang, Qunyuan, Huffman, Jennifer E., Crosby, Jacy, Wassel, Christina L., Do, Ron, Franceschini, Nora, Martin, Lisa W., Robinson, Jennifer G., Assimes, Themistocles L., Crosslin, David R., Rosenthal, Elisabeth A., Tsai, Michael, Rieder, Mark J., Farlow, Deborah N., Folsom, Aaron R., Lumley, Thomas, Fox, Ervin R., Carlson, Christopher S., Peters, Ulrike, Jackson, Rebecca D., van Duijn, Cornelia M., Uitterlinden, André G., Levy, Daniel, Rotter, Jerome I., Taylor, Herman A., Gudnason, Vilmundur, Siscovick, David S., Fornage, Myriam, Borecki, Ingrid B., Hayward, Caroline, Rudan, Igor, Chen, Y. Eugene, Bottinger, Erwin P., Loos, Ruth J.F., Sætrom, Pål, Hveem, Kristian, Boehnke, Michael, Groop, Leif, McCarthy, Mark, Meitinger, Thomas, Ballantyne, Christie M., Gabriel, Stacey B., O’Donnell, Christopher J., Post, Wendy S., North, Kari E., Reiner, Alexander P., Boerwinkle, Eric, Psaty, Bruce M., Altshuler, David, Kathiresan, Sekar, Lin, Dan-Yu, Jarvik, Gail P., Cupples, L. Adrienne, Kooperberg, Charles, Wilson, James G., Nickerson, Deborah A., Abecasis, Goncalo R., Rich, Stephen S., Tracy, Russell P., Willer, Cristen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928660/
https://ncbi.nlm.nih.gov/pubmed/24507775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.01.010
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