Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To...

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Hlavní autoři: Lange, Leslie A., Hu, Youna, Zhang, He, Xue, Chenyi, Schmidt, Ellen M., Tang, Zheng-Zheng, Bizon, Chris, Lange, Ethan M., Smith, Joshua D., Turner, Emily H., Jun, Goo, Kang, Hyun Min, Peloso, Gina, Auer, Paul, Li, Kuo-ping, Flannick, Jason, Zhang, Ji, Fuchsberger, Christian, Gaulton, Kyle, Lindgren, Cecilia, Locke, Adam, Manning, Alisa, Sim, Xueling, Rivas, Manuel A., Holmen, Oddgeir L., Gottesman, Omri, Lu, Yingchang, Ruderfer, Douglas, Stahl, Eli A., Duan, Qing, Li, Yun, Durda, Peter, Jiao, Shuo, Isaacs, Aaron, Hofman, Albert, Bis, Joshua C., Correa, Adolfo, Griswold, Michael E., Jakobsdottir, Johanna, Smith, Albert V., Schreiner, Pamela J., Feitosa, Mary F., Zhang, Qunyuan, Huffman, Jennifer E., Crosby, Jacy, Wassel, Christina L., Do, Ron, Franceschini, Nora, Martin, Lisa W., Robinson, Jennifer G., Assimes, Themistocles L., Crosslin, David R., Rosenthal, Elisabeth A., Tsai, Michael, Rieder, Mark J., Farlow, Deborah N., Folsom, Aaron R., Lumley, Thomas, Fox, Ervin R., Carlson, Christopher S., Peters, Ulrike, Jackson, Rebecca D., van Duijn, Cornelia M., Uitterlinden, André G., Levy, Daniel, Rotter, Jerome I., Taylor, Herman A., Gudnason, Vilmundur, Siscovick, David S., Fornage, Myriam, Borecki, Ingrid B., Hayward, Caroline, Rudan, Igor, Chen, Y. Eugene, Bottinger, Erwin P., Loos, Ruth J.F., Sætrom, Pål, Hveem, Kristian, Boehnke, Michael, Groop, Leif, McCarthy, Mark, Meitinger, Thomas, Ballantyne, Christie M., Gabriel, Stacey B., O’Donnell, Christopher J., Post, Wendy S., North, Kari E., Reiner, Alexander P., Boerwinkle, Eric, Psaty, Bruce M., Altshuler, David, Kathiresan, Sekar, Lin, Dan-Yu, Jarvik, Gail P., Cupples, L. Adrienne, Kooperberg, Charles, Wilson, James G., Nickerson, Deborah A., Abecasis, Goncalo R., Rich, Stephen S., Tracy, Russell P., Willer, Cristen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928660/
https://ncbi.nlm.nih.gov/pubmed/24507775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.01.010
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