Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To...

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Main Authors: Lange, Leslie A., Hu, Youna, Zhang, He, Xue, Chenyi, Schmidt, Ellen M., Tang, Zheng-Zheng, Bizon, Chris, Lange, Ethan M., Smith, Joshua D., Turner, Emily H., Jun, Goo, Kang, Hyun Min, Peloso, Gina, Auer, Paul, Li, Kuo-ping, Flannick, Jason, Zhang, Ji, Fuchsberger, Christian, Gaulton, Kyle, Lindgren, Cecilia, Locke, Adam, Manning, Alisa, Sim, Xueling, Rivas, Manuel A., Holmen, Oddgeir L., Gottesman, Omri, Lu, Yingchang, Ruderfer, Douglas, Stahl, Eli A., Duan, Qing, Li, Yun, Durda, Peter, Jiao, Shuo, Isaacs, Aaron, Hofman, Albert, Bis, Joshua C., Correa, Adolfo, Griswold, Michael E., Jakobsdottir, Johanna, Smith, Albert V., Schreiner, Pamela J., Feitosa, Mary F., Zhang, Qunyuan, Huffman, Jennifer E., Crosby, Jacy, Wassel, Christina L., Do, Ron, Franceschini, Nora, Martin, Lisa W., Robinson, Jennifer G., Assimes, Themistocles L., Crosslin, David R., Rosenthal, Elisabeth A., Tsai, Michael, Rieder, Mark J., Farlow, Deborah N., Folsom, Aaron R., Lumley, Thomas, Fox, Ervin R., Carlson, Christopher S., Peters, Ulrike, Jackson, Rebecca D., van Duijn, Cornelia M., Uitterlinden, André G., Levy, Daniel, Rotter, Jerome I., Taylor, Herman A., Gudnason, Vilmundur, Siscovick, David S., Fornage, Myriam, Borecki, Ingrid B., Hayward, Caroline, Rudan, Igor, Chen, Y. Eugene, Bottinger, Erwin P., Loos, Ruth J.F., Sætrom, Pål, Hveem, Kristian, Boehnke, Michael, Groop, Leif, McCarthy, Mark, Meitinger, Thomas, Ballantyne, Christie M., Gabriel, Stacey B., O’Donnell, Christopher J., Post, Wendy S., North, Kari E., Reiner, Alexander P., Boerwinkle, Eric, Psaty, Bruce M., Altshuler, David, Kathiresan, Sekar, Lin, Dan-Yu, Jarvik, Gail P., Cupples, L. Adrienne, Kooperberg, Charles, Wilson, James G., Nickerson, Deborah A., Abecasis, Goncalo R., Rich, Stephen S., Tracy, Russell P., Willer, Cristen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928660/
https://ncbi.nlm.nih.gov/pubmed/24507775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.01.010
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