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Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
We describe the potential benefit of PIK-75 in combination of gemcitabine to treat pancreatic cancer in a preclinical mouse model. The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative PCR, DNA-binding and western blot ana...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928470/ https://ncbi.nlm.nih.gov/pubmed/24366069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.2229 |
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