Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine

We describe the potential benefit of PIK-75 in combination of gemcitabine to treat pancreatic cancer in a preclinical mouse model. The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative PCR, DNA-binding and western blot ana...

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Main Authors: DUONG, HONG-QUAN, YI, YONG WEON, KANG, HYO JIN, HONG, YOUNG BIN, TANG, WENXI, WANG, ANTAI, SEONG, YEON-SUN, BAE, INSOO
格式: Artigo
語言:Inglês
出版: D.A. Spandidos 2013
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928470/
https://ncbi.nlm.nih.gov/pubmed/24366069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.2229
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