Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine

Checkpoint kinase 2 (CHK2) plays pivotal function as an effector of cell cycle checkpoint arrest following DNA damage. Recently, we found that co-treatment of NSC109555 (a potent and selective CHK2 inhibitor) potentiated the cytotoxic effect of gemcitabine (GEM) in pancreatic cancer MIA PaCa-2 cells...

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Autores principales: Duong, Hong-Quan, Hong, Young Bin, Kim, Jung Soon, Lee, Hee-Seok, Yi, Yong Weon, Kim, Yeon Jeong, Wang, Antai, Zhao, Wenjing, Cho, Chi Heum, Seong, Yeon-Sun, Bae, Insoo
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159025/
https://ncbi.nlm.nih.gov/pubmed/23855452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12101
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