Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine

Checkpoint kinase 2 (CHK2) plays pivotal function as an effector of cell cycle checkpoint arrest following DNA damage. Recently, we found that co-treatment of NSC109555 (a potent and selective CHK2 inhibitor) potentiated the cytotoxic effect of gemcitabine (GEM) in pancreatic cancer MIA PaCa-2 cells...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Duong, Hong-Quan, Hong, Young Bin, Kim, Jung Soon, Lee, Hee-Seok, Yi, Yong Weon, Kim, Yeon Jeong, Wang, Antai, Zhao, Wenjing, Cho, Chi Heum, Seong, Yeon-Sun, Bae, Insoo
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159025/
https://ncbi.nlm.nih.gov/pubmed/23855452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12101
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky